If gaming with Nvidia hardware is your primary concern, then maybe Bazzite would suit you. It’s based on Immutable Fedora, with tweaks to give it a SteamOS like experience. It offers Gnome or KDE for the desktop, and supposedly has everything dialed in for gaming. I’ve heard a bunch about it doing great with Nvidia cards and gaming in general, I suspect that you’d be able to do everything else you might need via the desktop it provides, but I have no knowledge of how it handles multiple monitors so maybe therein lies the fatal flaw.
I’m now deeply curious if it works for your use case. Hit me back if you give it a go and let me know if it works out or not.